Klonopin assay using modified electrode with multiwalled carbon nanotubes and poly melamine nanocomposite

Klonopin assay using modified electrode with multiwalled carbon nanotubes and poly melamine nanocomposite


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علوم پزشکی شهید بهشتی
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نویسندگان: شکوه السادات خالو

کلمات کلیدی: KlonopinMelamineCarbon nanotubeGlassy carbon electrodeVoltammetricDetermination

نشریه: Materials science & engineering. C, Materials for biological applications, 1,99,121 - 128,2019

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کد مقاله 66017949
عنوان فارسی مقاله Klonopin assay using modified electrode with multiwalled carbon nanotubes and poly melamine nanocomposite
عنوان لاتین مقاله Klonopin assay using modified electrode with multiwalled carbon nanotubes and poly melamine nanocomposite
نوع مقاله اصیل پژوهشی - Original Article
نحوه ایندکس شدن مقاله Science Sitation Index Expanded -ISI - Web of Science
IF 5.08
عنوان نشریه Materials science & engineering. C, Materials for biological applications
نوع نشریه خارجی نمایه شده
شماره نشریه 1
دوره 99
صفحه شروع و پایان در نشریه 121 - 128
سال انتشار/ ارائه شمسی 1398
سال انتشار/ارائه میلادی 2019
آدرس لینک مقاله/ همایش در شبکه اینترنت https://www.sciencedirect.com/science/article/pii/S0928493118331278
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آدرس علمی (Affiliation) نویسنده متقاضی Department of Health, Safety and Environment, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Developing of cheap, sensitive and stable sensors plays a significant role in pharmaceutical and clinical applications. Considering the effective role of Klonopin (KNP) in the treatment of epilepsy, KNP quantification in its production process for dose adjustments and checking the purity and also after its usage by patents for bioavailability testing and effectiveness assay is vital. In present work, an efficient electrochemical sensor based on poly melamine and multiwalled carbon nanotubes nanocomposite (PMela/CNTs) was constructed which displayed effective electrochemical response toward KNP. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square-wave voltammetry (SWV) experiments were applied for performance evaluation of the PMela/CNTs modified electrode and electrochemical redox behavior of KNP. Distinguish synergetic effect was observed between CNTs and poly melamine in response to KNP electrochemical redox reaction. A linear detection range of 0.05 to 10 μM with the detection limits of 63 nM was achieved for KNP analysis. The practical application of the PMela/CNTs modified electrode revealed satisfactory results for quantification of KNP in biological fluids.

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شکوه السادات خالودوم

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Klonopin assay using modified electrode.pdf1398/02/102339718دانلود